Studies on Experimental Models (Oxidative Stress in Applied Basic Research and Clinical Practice)

1. Role of Oxidative Stress and Targeted Antioxidant Therapies in Experimental Models of Diabetic Complications
2. Experimental Models of Oxidative Stress Related to Cardiovascular Diseases and Diabetes
3. Arachidonic Acid Metabolism and Lipid Peroxidation in Stroke: Alpha-Tocotrienol as a Unique Therapeutic Agent
4. Assessment of Oxidative Stress in the Brain of Spontaneously Hypertensive Rat and Stroke-Prone Spontaneously Hypertensive Rat Using by Electron Spin Resonance Spectroscopy
5. Small Heat Shock Proteins and Doxorubicin-Induced Oxidative Stress in the Heart .
6. Oxidative Stress in Cardiovascular Disease: Potential Biomarkers and Their Measurements
7. In vivo Imaging of Antioxidant Effects on NF- kB Activity in Reporter Mice
8. MPTP and Oxidative Stress: It’s Complicated
9. Oxidative Stress in Alzheimer’s Disease: A Critical Appraisal of the Causes and the Consequences
10. Retinal Disturbances in Patients and Animal Models with Huntington’s, Parkinson’s and Alzheimer’s Disease
11. Stress Gene Deregulation in Alzheimer Peripheral Blood Mononuclear Cells
12. The Use of Gpx4 Knockout Mice and Transgenic Mice to Study the Roles of Lipid Peroxidation in Diseases and Aging
13. An Experimental Model of Myocardial and Cerebral Global Ischemia and Reperfusion
14. Neovascular Models of the Rabbit Eye Induced By Hydroperoxide
15. Purinergic Signaling Involved in the Volume Regulation of Glial Cells in the Rat Retina: Alteration in Experimental Diabetes
16. Helicobacter pylori-Induced Oxidative Stress and Inflmmation
17. Experimental Models for Ionizing Radiation Research
18. Experimental Models to Study Cigarette Smoke-Induced Oxidative Stress In Vitro and In Vivo in Preclinical Models, and in Smokers and Patients with Airways Disease
19. Exhaled Breath Condensate Biomarkers of Airway Inflmmation and Oxidative Stress in COPD
20. Induction of Oxidative Stress by Iron/Ascorbate in Isolated Mitochondria and by UV Irradiation in Human Skin
21. Carbon Tetrachloride-Induced Hepatotoxicity: A Classic Model of Lipid Peroxidation and Oxidative Stress
22. Enhanced Urinary Excretion of Lipid Metabolites Following Exposure to Structurally Diverse Toxicants: A Unique Experimental Model for the Assessment of Oxidative Stress
23. Oxidative Stress in Animal Models with Special Reference to Experimental Porcine Endotoxemia
24. Models and Approaches for the Study of Reactive Oxygen Species Generation and Activities in Contracting Skeletal Muscle
25. Exercise as a Model to Study Interactions Between Oxidative Stress and Inflmmation
26. Exercise as a Model to Study Oxidative Stress
27. Models of Mitochondrial Oxidative Stress
28. Protection of Oxidant-Induced Neuronal Cells Injury by a Unique Cruciferous Nutraceutical
29. Oxidatively Generated Damage to DNA and Biomarkers
30. Measuring Oxidative Stress in Cell Cultures, Animals and Humans: Analysis and Validation of Oxidatively Damaged DNA
31. The Roles of cAMP and G Protein Signaling in Oxidative Stress-Induced Cardiovascular Dysfunction
32. Cellular and Chemical Assays for Discovery of Novel Antioxida

There is a widespread consensus that use of antioxidants as a therapeutic approach may counteract free radical mediated pathologies. However, the role of antioxidants in normal physiology and redox signaling is still in its infancy. Since oxidative stress is related to various diseases and pathologies, scientists are eager to study the disease in humans, but it is not always ethical to study all the aspects of the disease in humans. Thus, it becomes mandatory to study the disease process and the mechanisms behind it through experimental models which generally involve animals, in vitro/cell culture studies, primates and even humans to a certain extent. Studies on Experimental Models contains data on the experimental models or review of such models of oxidative stress in various diseases. It is structured into six sections, which are as follows: diabetes, cardiovascular, neurology, ocular diseases, toxicology/environmental and in vitro/tissue culture. Each section presents a sketch of models in humans, animals and in vitro methods. Taken together, they comprise a valuable reference for basic and clinical scientists, one aimed at contributing to the advancement of oxidative stress research using appropriate animal models