Book Details
Orange Code:57304
Paperback:670 pages
Publications:
Categories:
Sections:
1. Challenges for the Vaccine Developer, including Correlates of Protection2. Shaping Adaptive Immunity against Pathogens: The Contribution of Innate Immune Responses3. Adjuvant-induced Th2- and Th1-dominated Immune Responses in Vaccination4. Memory5. T Cell-based Vaccines6. Microbial Adjuvants7. Host-derived Adjuvants8. Microparticles as vaccine adjuvants and delivery systems9. Liposomes and ISCOMs10. Virosomal Technology and Mucosal Adjuvants11. Classical Bacterial Vaccines12. Subunit Vaccines and Toxoids13. Engineering Virus Vectors for Subunit Vaccines14. Update on antiviral DNA vaccine research (2000–2003)15. Live Recombinant Bacterial Vaccines16. Mucosal Vaccination17. PassiveVaccination and Antidotes: A Novel Strategy for Generation of Wide-spectrum Protective Antibodies18. Plant-based Oral Vaccines19. Virus-like Particles: Combining Innate and Adaptive Immunity for Effective Vaccination20. Helicobacter pylori21. Novel Vaccination Strategies against Tuberculosis22. Rationale for Malaria Vaccine Development23. Vaccine for Specific Targets: HIV24. Vaccines against Bioterror Agents25. Imperfect Vaccines and the Evolution of Pathogen Virulence26. Cost-Effectiveness of Vaccinations27. Immunological Safety of Vaccines: Facts, Hypothesesand Allegations
Description:
The protection mode of most available vaccines is based on antibody responses. Since efficient immune responses to many pathogens rely on activating all arms of the immune system, traditional vaccine development does not provide efficient protection against many diseases. Novel vaccination strategies need to allow presentation of antigens that activate the full array of the immune response in the right composition and should prevent pathogen entry by mobilizing the mucosal immune response. New technological advances optimize the immunogenicity of 'live' and sub--unit vaccines. This book offers an interdisciplinary overview on research and future strategies for rational vaccine design based on recent developments in molecular biology and immunology. It covers new aspects of the immunological interplay between prokaryotic and eukaryotic systems as well as achievements in the development of novel vaccine candidates. Chapters on edible vaccines, on vaccines against bioterror agents and on economical and safety aspects of novel vaccine development round off this title.
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