Drug Targets in Kinetoplastid Parasites

1. Arsenite Resistance in Leishmania and Possible Drug Targets
2. Unique Characteristics of the Kinetoplast DNA Replication Machinery Provide Potential Drug Targets in Trypanosomatids
3. Drugs and Transporters in Kinetoplastid Protozoa
4. Selective Lead Compounds against Kinetoplastid Tubulin
5. Fishing for Anti-Leishmania Drugs: P dples and Problems
6. Sterol 14-Demethylase Inhibitors for Trypanosoma cruzi Infections
7. Histone Deacetytases
8. Targeting Glycoproteins or Glycolipids and Their Metabolic Pathways for Antiparasite Therapy
9. DNA Topoisomerases of Leishmania: The Potential Targets for Anti-Leishmanial Therapy
10. Antiparasitic Chemotherapy: Tinkering with the Purine Salvage Pathway
11. Searching the Tritryp Genomes for Drug Targets
12. Purine and Pyri dine Metabolism in Leishmania

The dreaded protozoal diseases caused by a number of Kinetoplastid parasites threaten mankind, as therapeutic tools for the treatment of most parasitic diseases are extremely limited. Development of commercially available vaccines is still far from reality, though research and trial programs continue. This book covers current research into drug therapeutics for the conditions caused by the parasites, which if viewed globally, pose an increasing threat to human health and welfare.