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Global perspectives of cardiovascular disease have been enhanced
in all chapters where appropriate and by the addition of a new
chapter on global cardiovascular health (Chapter 43), which enhances the usefulness and generalizability of the content. A majority of the national clinical protocols were replaced with
evidence-based protocols. Numerical citations were reintroduced
to allow for more rapid identification of content related to specific areas. One new chapter on mechanical assist devices (Chapter
26) has been added. Other chapters, for example, Chapter 5 on
pathophysiology of atherosclerosis and acute coronary syndrome
and Chapter 24 on heart failure and cardiogenic shock, have
been combined and reorganized to allow for more comprehensive coverage of the materials. There have been many changes in
the care of cardiac patients since the fifth edition. Thus, all chapters have been updated to reflect the most current evidencebased practice guidelines.
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