Book Details
Orange Code:54163
Paperback:446 pages
Publications:
Categories:
Sections:
1. INTRODUCTION2. GENOMIC STRUCTURE3. GENOME EVOLUTION4. GENOMIC REARRANGEMENTS AND DISEASE TRAITS5. FUNCTIONAL ASPECTS OF GENOME STRUCTURE6. GENOMIC DISORDERS: MODELING AND ASSAYS7. APPENDICES
Description:
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A grand summary and synthesis of the tremendous amount of data now available in the post genomic era on the structural features, architecture, and evolution of the human genome. The authors demonstrate how such architectural features may be important to both evolution and to explaining the susceptibility to those DNA rearrangements associated with disease. Technologies to assay for such structural variation of the human genome and to model genomic disorders in mice are also presented. Two appendices detail the genomic disorders, providing genomic features at the locus undergoing rearrangement, their clinical features, and frequency of detection
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