Zebrafish: Methods for Assessing Drug Safety and Toxicity

1. The Reprodu ctive Biol ogy and Spawnin g of Zebrafish in Labo ratory Settings
2. Developmental Toxicity Assessment in Zebrafish
3. Use of Emerging Models for Developmental Toxicity Testing
4. Assessment of Drug-Induced Cardiotoxicity in Zebrafish
5. Cardiot oxicity Studie s in Zebrafish
6. In Vivo Recording of the Adult Zebrafish Electrocardiogram
7. Hematopoietic and Vascular System Toxicity
8. Hepatotoxicity Testing in Larval Zebrafish
9. W hole Zebrafish Cyto chrome P450 Assay for Assess ing Drug Metab olism and Safet y
10. Methods for Assessing Neurotoxicity in Zebrafish
11. Zebrafish: A Predictive Model for Assessing Cancer Drug-Induced Organ Toxicity
12. Locomotion and Behavioral Toxicity in Larval Zebrafish: Background, Methods, and Data
13. Zebrafish: A Predictive Model for Assessing Seizure Liability
14. Zebrafish: A New In Vivo Model for Identifying P-Glycoprotein Efflux Modulators
15. Assessment of Effects on Visual Function in Larval Zebrafish
16. Development of a Hypoxia-Induced Zebrafish Choroidal Neovascularization Mode
17. Zebrafish Xenotransplant Cancer Model for Drug Screening
18. Zebrafish Assays for Identifying Potential Muscular Dystrophy Drug Candidates
19. Cyt oprotecti ve Activ ities of Wate r-Solu ble Fullerene s in Zebrafish Model s
20. Fishing to Design Inherently Safer Nanoparticles
21. Radiation-Induced Toxicity and Radiation Response Modifiers in Zebrafish
22. Caudal Fin Regenera tion in Zebrafish

Zebrafish: Methods for Assessing Drug Safety and Toxicity offers a practical guide for using zebrafish as a tool for toxicology studies.  Consolidating key protocols and approaches to help researchers navigate the important and evolving field of zebrafish models for toxicity screening, this new title describes the methods for using the zebrafish as a model organism to assess compound-induced toxicity on all major organs.  Individual chapters that concentrate on assays for each organ system are included and various analytical tools including microscopy, microplate readers, high content imaging systems, ECG, blood pressure monitors, high speed video and motion detectors are described.