Computational Biophysics of the Skin

1. Multilayer Modeling of Skin Color and Translucency
2. Dermal Component–Based Optical Modeling of Skin Translucency: Impact on Skin Color
3. Mathematics and Biological Process of Skin Pigmentation
4. State-of-the-Art Constitutive Models of Skin Biomechanics
5. Fiber-Matrix Models of the Dermis
6. Cellular-Scale Mechanical Model of the Human Stratum Corneum
7. Mathematical Models of Skin Permeability: Microscopic Transport Models and Their Predictions
8. Cellular Scale Modelling of the Skin Barrier
9. Molecular Scale Modeling of Human Skin Permeation
10. Accessing the Molecular Organization of the Stratum Corneum Using High-Resolution Electron Microscopy and Computer Simulation
11. Water Diffusion through Stratum Corneum
12. Accurate Multiscale Skin Model Suitable for Determining the Sensitivity and Specificity of Changes of Skin Components
13. Model-Based Quantification of Skin Microcirculatory Perfusion
14. Graphical Multi-Scale Modeling of Epidermal Homeostasis with EPISIM
15. Heuristic Modelling Applied to Epidermal Homeostasis

The accessibility of the skin in vivo has resulted in the development of non-invasive methods in the past 40 years that offer accurate measurements of skin properties and structures from microscopic to macroscopic levels. However, the mechanisms involved in these properties are still only partly understood. Similar to many other domains, including biomedical engineering, numerical modeling has appeared as a complementary key actor for improving our knowledge of skin physiology.   This book presents, for the first time, the contributions that focus on scientific computing and numerical modeling to offer a deeper understanding of the mechanisms involved in skin physiology. The book is structured around some skin properties and functions, including optical and biomechanical properties and skin barrier function and homeostasis, with—for each of them—several chapters that describe either biological or physical models at different scales.