Neurotrophic Factors

1. Deciphering Proneurotrophin Actions
2. Spatiotemporal Intracellular Dynamics of Neurotrophin and Its Receptors. Implications for Neurotrophin Signaling and Neuronal Function
3. Neurotrophins: Transcription and Translation
4. Trk Receptors
5. The Biological Functions and Signaling Mechanisms of the p75 Neurotrophin Receptor
6. Sortilins in Neurotrophic Factor Signaling
7. Neurotrophins i n the Regulation of Cellular Survival and Death
8. BDNF and Synaptic Plasticity, Cognitive Function, and Dysfunction
9. Nerve Growth Factor and Nociception: From Experimental Embryology to New Analgesic Therapy
10. Neurotrophins and the Regulation of Energy Balance and Body Weight
11. The Biology of Neurotrophins: Cardiovascular Function
12. Neurotrophin Signalling and Transcription Programmes Interactions in the Development o f Somatosensory Neurons
13. Huntington’s Disease
14. Motoneuron Disease
15. Neurotrophic Factors in Spinal Cord Injury
16. Modulation of Neurotrophin Signaling by Monoclonal Antibodies

This book provides critical reviews of the role of neurotrophins and their receptors in a wide variety of diseases including neurodegenerative diseases like Huntington’s syndrome, cognitive function, psychiatric disorders such as clinical depression, Rett syndrome, motoneurone disease, spinal cord injury, pain, metabolic disease and cardiovascular disease. It also contains contributions from leaders in the field dealing with the basic biology, transcriptional and post-translational regulation of the neurotrophins and their receptors. The present book will review all recent areas of progress in the study of neurotrophins and their biological roles.