Metronomic Chemotherapy: Pharmacology and Clinical Applications

1. Development and Evolution of the Concept of Metronomic Chemotherapy: A Personal Perspective
2. Mechanisms of Action of Low-Dose Metronomic Chemotherapy
3. Effects of Metronomic Chemotherapy on Immunity
4. Preclinical Activity of Metronomic Regimens with Alkylating Agents and Antimetabolites
5. Metronomic Chemotherapy Regimens Using Microtubule-Targeting Agents: Mechanisms of Action, Preclinical Activity and Future Developments
6. Metronomic Chemotherapy in Breast Cancers
7. Overview of Metronomic Chemotherapy in SWOG Breast Cancer Cooperative Group Clinical Trials
8. Clinical Trials of Low-Dose Metronomic Chemotherapy in Castration-Resistant Prostate Cancer
9. The Role of Metronomic Chemotherapy in the Treatment of Metastatic Colorectal Cancer Patients
10. Clinical Activity of Metronomic Chemotherapy in Central Nervous System Cancers
11. Metronomic Chemotherapy in Pediatric Malignancies
12. Metronomic Chemotherapy in Hematological Malignancies
13. Clinical Activity of Metronomic Chemotherapy in Liver Cancers
14. Metronomic Chemotherapy in Gynecological Cancers
15. Pharmacokinetics and Pharmacogenetics of Metronomic Chemotherapy
16. Metronomics: Potential Social Impact and New Business Models to Improve Availability of Cancer Treatments
17. Clinical Studies of Metronomic Chemotherapy in Dogs

This book analyzes all aspects of metronomic chemotherapy, a new approach involving low-dose, long-term, and frequently administered therapy that has preclinical and clinical activity in various tumors. After an opening section on the pharmacological bases of metronomic chemotherapy, including its antiangiogenic effects and impact on immunity, preclinical studies on various classes of drug are discussed. Clinical applications of metronomic chemotherapy in a wide variety of tumors are then addressed in detail, with description of the results of all published studies. The clinical pharmacology of metronomic chemotherapy is also considered in depth, encompassing pharmacokinetics, pharmacogenetics, pharmacoeconomics, and adverse drug reactions. The book closes by describing the role of this therapy in the veterinarian clinic.