Developmental Aspects of the Lymphatic Vascular System

1. Introductory Remarks
2. Transcriptional Control of Lymphatic Endothelial Cell Type Specification
3. Mechanosensing in Developing Lymphatic Vessels
4. Plasticity of Airway Lymphatics in Development and Disease
5. Regulation of Lymphatic Vasculature by Extracellular Matrix
6. Interplay of Mechanotransduction, FOXC2, Connexins, and Calcineurin Signaling in Lymphatic Valve Formation
7. Development of Secondary Lymphoid Organs in Relation to Lymphatic Vasculature
8. Platelets in Lymph Vessel Development and Integrity
9. Interactions of Immune Cells and Lymphatic Vessels
10. Lymphatic Vessels in the Development of Tissue and Organ Rejection
11. The Role of Neuropilin-1/Semaphorin 3A Signaling in Lymphatic Vessel Development and Maturation
12. A Fisheye View on Lymphangiogenesis
13. Visualization of Lymphatic Vessel Development, Growth, and Function
14. Clinical Disorders of Primary Malfunctioning of the Lymphatic System

The book focuses on the lymphatic vascular system from a developmental biologist’s point of view. It provides an overview on the many recent advances in understanding the development of lymphatic vessels, using advanced genetic models in conjunction with state of the art imaging. For each chapter a synopsis is provided, highlighting the main points in a concise manner. The book is intended for professors and researchers in vascular biology, angiogenesis research and developmental biology. It furthermore offers an excellent basis for entry level researchers and newcomers to this field, as well as for teachers, graduate students, advanced science and medical students.