Vascular-Targeted Therapies in Oncology

1. Tumor Vasculature: a Target for Anticancer Therapies
2. Abnormal Microvasculature and Defective Microcirculatory Function in Solid Tumors
3. The Role of Microvasculature in Metastasis Formation
4. Development of Agents that Selectively Disrupt Tumor Vasculature: A Historical Perspective
5. Molecular Recognition of the Colchicine Binding Site as a Design Paradigm for the Discovery and Development of Vascular Disrupting Agents
6. Combined Modality Approaches Using Vasculature-disrupting Agents
7. Vasculature-targeting Therapies and Hyperthermia
8. Flavones and Xanthenones as Vascular-disrupting Agents
9. Targeting Inside-Out Phospholipids on Tumor Blood Vessels in Pancreatic Cancer
10. Cadherin Antagonists as Vasculature-targeting Agents
11. Imaging the Effects of Vasculature-targeting Agents
12. Clinical Progress in Tumor Vasculature-disrupting Therapies
13. Use of Vasculature-disrupting Agents in Non-Oncology Indications

Vascular-Targeted Therapies in Oncology provides an interesting insight to the current status and future potential of vascular-disrupting approaches in cancer management. Emphasis is placed on target development, preclinical assessment, and the use of such targeted approaches in combination with conventional treatment regimens and the current clinical status of these therapies.