Viral Oncology Basic Science and Clinical Applications

1. HUMAN PAPILLOMAVIRUS-ASSOCIATED CANCERS
2. MOLECULAR EVENTS ASSOCIATED WITH HUMAN PAPILLOMAVIRUS-INDUCED HUMAN CANCERS
3. THE ROLE OF THE HUMAN PAPILLOMAVIRUS E6 ONCOPROTEIN IN MALIGNANT PROGRESSION
4. JC VIRUS ASSOCIATION WITH BRAIN TUMORS: THE ROLE OF T ANTIGEN AND INSULIN-LIKE GROWTH FACTOR 1 IN DNA REPAIR FIDELITY
5. INVOLVEMENT OF THE POLYOMAVIRUS, JC VIRUS, IN COLORECTAL CANCER
6. POSSIBLE ASSOCIATION OF BK VIRUS WITH PROSTATE CANCER
7. ONCOGENIC TRANSFORMATION BY POLYOMAVIRUS LARGE T ANTIGEN
8. SIMIAN VIRUS 40, HUMAN INFECTIONS, AND CANCER: EMERGING CONCEPTS AND CAUSALITY CONSIDERATIONS
9. SIMIAN VIRUS 40 AND MESOTHELIOMA
10. MOLECULAR IMMUNOBIOLOGY OF HEPATITIS B-ASSOCIATED VIRAL CANCER
11. HEPATITIS B VACCINE AND HEPATOCELLULAR CARCINOMA
12. PATHOGENESIS OF ACUTE AND CHRONIC HEPATITIS C VIRUS INFECTION
13. MOLECULAR MECHANISMS OF HEPATITIS C VIRUS-INDUCED CELLULAR TRANSFORMATION
14. THE ROLE OF KSHV IN PATHOGENESIS OF KAPOSI’S SARCOMA
15. MOLECULAR PATHOBIOLOGY OF EBV INFECTION
16. EPSTEIN–BARR VIRUS AS A PATHOGEN

Clinical oncologists and researchers now have a comprehensive single source of current information on cancer viruses obtained from bench and bedside. This important refernce allows further development of translational approaches for the effective treatment of patients with virus-associated malignancies. The book contains 25 chapters covering basic and clinical aspects of viruses, including HPV, HBV, HCV, polyomaviruses, Kaposi's associated viruses, retroviruses (including HIV-1 associated malignancies), and EBV. Several chapters are devoted to basic science of oncogenic viruses for the study of their pathogenesis, drug development, and employment of viral vectors for vaccine and gene therapy. Clinical materials are embedded within chapters, and there are also complementary, clinically based chapters describing natural courses and treatments.